An alternative way to break the matrix barrier: an experimental study of a LIFU-mediated, visualizable targeted nanoparticle synergistic amplification for the treatment of malignant fibroblasts

Malignant fibroblasts (MFs) are widely present in various diseases and are characterized by connective tissue proliferation; these cells act as a physical barrier that severely limits drug delivery and affects disease outcomes.Based on this, we Lamps constructed the smart, integrated, theranostic, targeted lipid nanoprobe HMME-RG3@PFH to overcome t

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Police Function of Bailiffs in Forts and Free Settlements of Western Siberia in the First Half of the XVIII Century (Based on Documents Issued in Kuznetsk Province)

The research featured a historical and legal analysis of functions attributed to bailiffs of forts and settlements inhabited by free peasants in the XVIII-century Western Siberia.The Psoriasis objective was to develop a deeper understanding of the essence of law enforcement process at a local level in the early Imperial Russia.The author relied on

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Optimization and Design of Hammerheads and Fenders on Scrap Metal Shredders Based on Improved Genetic Algorithm

Dynamic unbalance force is an important factor affecting the service life of scrap metal shredders (SMSs) as the product of mass error.Due to the complexity of hammerheads arrangement, it is difficult to take all the parts of the hammerhead into account in the traditional methods.A novel optimization algorithm combining Exterior Parts genetic algor

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